Excess Ub-K48 Induces Neuronal Apoptosis in Alzheimer’s Disease
Ub-K48 is strongly linked to the development of AD. p-Tau aggregate in neuronal cells in the hippocampal region of the AD brain and colocalize with Ub-K48, which in turn leads to cellular inflammation and the induction of apoptosis in neuronal cells.
Authors
- Yiyuan Yuan (ORCID: https://orcid.org/0000-0003-0829-3824)
- Jing Jiang (ORCID: https://orcid.org/0000-0001-7167-9848)
- Yuan‐Xiang Tao (ORCID: https://orcid.org/0000-0003-1777-3272)
- Guangfu Di (ORCID: https://orcid.org/0000-0001-9856-2025)
- Haoyuan Chen (ORCID: https://orcid.org/0000-0002-8634-4028)
- Yanjiao Huang
- Wenjun Fang (ORCID: https://orcid.org/0000-0002-5610-1623)
- Zhiliang Xu (ORCID: https://orcid.org/0000-0003-0527-605X)
- Shi Huang
- Yili Zhuang
Institutions
- Wannan Medical College (CN)
- First Affiliated Hospital of Wannan Medical College (CN)
Publication Details
- Journal
- Journal of Integrative Neuroscience
- Published
- 2024-12-24
- DOI
- https://doi.org/10.31083/j.jin2312223
- Citations
- 6
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.96
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Wannan Medical College