Substrate-Controlled Divergent Reductive Cyclization of 2-Arylanilines Using CO<sub>2</sub> as a Switching Reagent
Capturing CO<sub>2</sub> is highly valued in the field of organic synthesis, especially underdeveloped dual-CO<sub>2</sub> conversion. In this study, we detail a novel reductive cyclization of 2-indolylanilines with dual CO<sub>2</sub> as a difunctional reagent in the presence of PMHS [poly(methylhydrosiloxane)], delivering methyl-substituted quinoxalines. Furthermore, another chemoselective cyclization with 2-pyrrolylanilines is also realized by converting mono-CO<sub>2</sub>. Mechanistic investigations shed light upon the fact that this substrate-controlled divergence mainly depends on the formation of <i>N</i>-diacylative intermediates.
Authors
- Chengyuan Liang (ORCID: https://orcid.org/0000-0001-7360-8998)
- Qiang Yan (ORCID: https://orcid.org/0000-0002-5550-3612)
- Jiang Nan (ORCID: https://orcid.org/0000-0001-5570-6834)
- Lanxin Zhu (ORCID: https://orcid.org/0000-0002-2721-9673)
- Chen Zhang (ORCID: https://orcid.org/0009-0004-3697-0954)
- Shilei Liu (ORCID: https://orcid.org/0000-0002-9053-8458)
- Rui Cao
Institutions
- Shaanxi University of Science and Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1021/acs.orglett.4c04538
- Citations
- 5
- Primary Topic
- Carbon dioxide utilization in catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.89
Funders
- National Natural Science Foundation of China