Brainstem C1 neurons mediate heart failure decompensation and mortality during acute salt loading
Our results strongly suggest that RVLM C1 neurons contribute to acute HF decompensation during salt loading by a mechanism encompassing further increases in sympathetic outflow and hypoxia-related breathing disorders. This mechanism may ultimately impact cardiac contractility through cardiomyocyte calcium mishandling, increasing morbidity and mortality.
Authors
- Karla G. Schwarz (ORCID: https://orcid.org/0000-0002-2503-3402)
- Sinay Vicencio (ORCID: https://orcid.org/0009-0004-7630-2651)
- Rodrigo Del Río (ORCID: https://orcid.org/0000-0002-2562-806X)
- Esteban Díaz‐Jara
- Katherin V. Pereyra
Institutions
- Pontificia Universidad Católica de Chile (CL)
- University of Kansas Medical Center (US)
- Universidad de Magallanes (CL)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1093/cvr/cvae261
- Citations
- 4
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Fondo Nacional de Desarrollo Científico y Tecnológico