Acetylation-ubiquitination crosstalk of DJ-1 mediates microcalcification formation in diabetic plaques via collagen-matrix vesicles interaction
In the diabetic microenvironment, DJ-1 was a protective factor for vascular microcalcification. NAT10- and TRIM32-mediated acetylation-ubiquitination crosstalk resulted in the degradation of DJ-1. The decrease of DJ-1 could activate DJ-1/STAT1/RAGE microcalcification signal. Further, under the stimulation of DJ-1-mediated microcalcification signal, VSMCs released MVs with high abundance of MFGE8. MFGE8 promoted collagen-MVs interaction and finally accelerated the formation of microcalcification.
Authors
- Yongjiang Qian
- Zhongqun Wang
- Yao Wu (ORCID: https://orcid.org/0000-0002-0524-4042)
- Guangyao Zang (ORCID: https://orcid.org/0000-0001-9381-3593)
- Haipeng Yao (ORCID: https://orcid.org/0000-0001-7160-7107)
- Lihua Li (ORCID: https://orcid.org/0000-0002-2089-8140)
- Lili Zhang (ORCID: https://orcid.org/0000-0003-3014-2766)
- Zhen Sun (ORCID: https://orcid.org/0009-0004-9382-0389)
- Xiang Mao (ORCID: https://orcid.org/0000-0001-8503-4557)
Institutions
- Jiangsu University (CN)
- Anhui Medical University (CN)
- Affiliated Hospital of Jiangsu University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1093/cvr/cvae263
- Citations
- 7
- Primary Topic
- Connective tissue disorders research
- Type
- article
- Field-Weighted Citation Impact
- 3.85
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province
- Jiangsu Provincial Key Research and Development Program