The impact of systemic immune inflammation index and neutrophil/lymphocyte ratio on mortality in patients undergoing surgery for infective endocarditis

Aims: Infective endocarditis (IE) is a severe cardiac pathology associated with high morbidity and mortality. Early identification of disease severity and mortality risk using simple, rapid, and cost-effective tests can significantly improve clinical outcomes. This study aims to provide clinicians with valuable information on the prognostic importance of SIII and NLR in the management of IE patients and to guide potentially more effective perioperative interventions. Methods: This study retrospectively investigates the relationship between the Systemic Immune Inflammation Index (SIII), Neutrophil/Lymphocyte Ratio (NLR), and mortality in patients who underwent surgical treatment for IE between March 2020 and November 2023. A total of 100 patients over the age of 18 were included in the study. Data were collected on various clinical parameters, and statistical analyses were performed using SPSS 26.0. Results: Patients who experienced mortality had significantly higher mean SIII (1953.6 vs. 1352.4, p=0.003) and NLR (8.5 vs. 5.7, p=0.007) values than those who survived. These high indices in the mortality group suggest a stronger inflammatory response and immune dysregulation, making SIII and NLR useful indicators for assessing the prognosis of patients with infective endocarditis. Conclusion: The study underscores the potential of these indices as reliable markers for predicting mortality and disease severity in IE, ultimately aiding in better patient stratification and management.