CD36-mediated uptake of oxidized LDL induces double-negative regulatory T cell ferroptosis in metabolic dysfunction-associated steatotic liver disease
oxLDL induces a decline in the survival and immune regulatory function of DNT, subsequently weakening their role in maintaining liver immune homeostasis in MASLD. Specific targeting of CD36 to prevent ferroptosis in DNT may provide a novel therapeutic approach for the treatment of MASLD.
Authors
- Changying Li (ORCID: https://orcid.org/0000-0002-0115-7507)
- Guangyong Sun (ORCID: https://orcid.org/0009-0000-1379-5752)
- Jie Sun (ORCID: https://orcid.org/0000-0002-0932-7195)
- Yuan Jiang (ORCID: https://orcid.org/0000-0003-4307-0562)
- Minjie Lin (ORCID: https://orcid.org/0000-0002-3780-2600)
- Shimeng Zheng
- Dong Zhang (ORCID: https://orcid.org/0000-0002-3404-5173)
- Mengyi Li (ORCID: https://orcid.org/0000-0002-1950-6752)
- Xiyu Wang (ORCID: https://orcid.org/0009-0002-7558-6504)
- Zhongtao Zhang (ORCID: https://orcid.org/0000-0002-3777-1154)
- Songlin Wang (ORCID: https://orcid.org/0000-0002-7435-2637)
- Xinjuan Liu (ORCID: https://orcid.org/0000-0001-7532-282X)
- Wen Shi (ORCID: https://orcid.org/0000-0002-2115-6157)
- Yunxiong Wei (ORCID: https://orcid.org/0000-0003-0088-7775)
- Jingjing Zhu
- Zihan Zhang (ORCID: https://orcid.org/0009-0000-5235-5178)
Institutions
- Central South University (CN)
- Capital Medical University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Beijing Friendship Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Metabolism
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1016/j.metabol.2024.156127
- Citations
- 15
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 6.28