Biochemical evaluation of novel thiazolone derivatives as dual α-glucosidase/α-amylase inhibitors, anti-inflammatory agents
Compounds (4 and 7) achieved the best effect as α-amylase inhibitors showed by IC<sub>50</sub> score near to that of control (Acarbose). Meanwhile, compound (4) exhibited a lower ferric-reducing anti-oxidant power (FRAP) value when compared to the control experiment (ascorbic acid). A molecular docking study approved the binding affinity and mode of binding of compounds (4 and 5) to the α-glucosidase and α-amylase binding pockets.
Authors
- Ibrahim M. El‐Deen (ORCID: https://orcid.org/0000-0003-3793-6235)
- Mohamed Ahmed Elian Sophy (ORCID: https://orcid.org/0000-0002-6615-1384)
- Moustafa S. Abdelhamid (ORCID: https://orcid.org/0000-0002-1212-8349)
- Salwa Samy Abdelfattah Eraky
Institutions
- Zagazig University (EG)
- Arish University (EG)
- Port Said University (EG)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2024-12-29
- DOI
- https://doi.org/10.1080/17568919.2024.2447225
- Citations
- 2
- Primary Topic
- Natural Antidiabetic Agents Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.72