Evaluation of methotrexate Pharmacogenomic variation to predict acute neurotoxicity in children with acute lymphoblastic leukemia
Overall, our results suggest that associations between neurotoxicity susceptibility and methotrexate pharmacogenomic variants are generally modest and these variants do not significantly improve neurotoxicity risk stratification among children with ALL.
Authors
- Kathleen Ludwig
- Mark Zobeck (ORCID: https://orcid.org/0000-0003-0997-906X)
- Michael E. Scheurer (ORCID: https://orcid.org/0000-0002-8379-6088)
- Juan Carlos Bernini
- Karen R. Rabin (ORCID: https://orcid.org/0000-0002-4081-8195)
- Han Chen (ORCID: https://orcid.org/0000-0002-9510-4923)
- Bing Yu
- Laura J. Klesse (ORCID: https://orcid.org/0000-0003-1323-7720)
- M. Brooke Bernhardt (ORCID: https://orcid.org/0000-0002-9612-3624)
- Van Huynh (ORCID: https://orcid.org/0000-0002-2781-5627)
- Sandi L. Pruitt (ORCID: https://orcid.org/0000-0002-1007-9176)
- Austin L. Brown (ORCID: https://orcid.org/0000-0001-5802-5073)
- Maria Monica Gramatges (ORCID: https://orcid.org/0000-0002-0947-104X)
- Amy E. Hughes (ORCID: https://orcid.org/0000-0002-1085-0282)
- Rodrigo Eraña
- Yoshiyuki Ohno (ORCID: https://orcid.org/0009-0005-4727-8792)
- Philip J. Lupo (ORCID: https://orcid.org/0000-0003-0978-5863)
- Kenneth Heym (ORCID: https://orcid.org/0000-0002-6635-435X)
- Olga A. Taylor
- A. Choi (ORCID: https://orcid.org/0000-0002-5636-233X)
- Melissa A. Richard (ORCID: https://orcid.org/0000-0003-0129-9860)
- Rachel D. Harris (ORCID: https://orcid.org/0000-0002-8191-5477)
- Ashley Chavana
- Alanna C. Morrison
- Timothy Griffin
Institutions
- Children's Hospital of Orange County (US)
- St. Jude Children's Research Hospital (US)
- Baylor College of Medicine (US)
- University of California, Irvine (US)
- Cook Children's Medical Center (US)
- Vannie E. Cook Jr. Cancer Foundation (US)
- Children's Cancer Center (US)
- The University of Texas Southwestern Medical Center (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
- Published
- 2024-12-29
- DOI
- https://doi.org/10.1002/phar.4638
- Citations
- 2
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 1.09
Funders
- Cancer Prevention and Research Institute of Texas
- St. Baldrick's Foundation
- National Institutes of Health
- National Cancer Institute