Clinicopathological characteristics of invasive stratified mucinous carcinoma of the cervix and the expression and clinical significance of SLC7A11, SLC3A2 and PD-L1
ISMC demonstrates a high rate of lymph node metastasis and a high recurrence rate, indicating strong invasiveness. Additionally, ISMC exhibits a wide morphological spectrum. SLC7A11, SLC3A2, and PD-L1 are all highly expressed in ISMC tissues. The high expression of SLC7A11 may indicate a high recurrence rate for ISMC. Immunotherapy with checkpoint inhibitors and iron death-related treatments show potential in the treatment of ISMC, with SLC7A11, SLC3A2, and PD-L1 serving as potential therapeutic targets for ISMC.
Authors
- Changyu Lu (ORCID: https://orcid.org/0000-0002-4839-7671)
- Ting Liu (ORCID: https://orcid.org/0000-0003-4157-4812)
- Xiuzhen Du (ORCID: https://orcid.org/0000-0002-4633-8328)
- Ce Zhang (ORCID: https://orcid.org/0000-0002-4961-5116)
- Wei‐Guo Zhu (ORCID: https://orcid.org/0000-0001-8385-6581)
- Xiahui Han (ORCID: https://orcid.org/0000-0002-5893-686X)
- Hui Zhang (ORCID: https://orcid.org/0000-0001-6028-2554)
- Yao Qin (ORCID: https://orcid.org/0000-0001-9303-6341)
Institutions
- Qingdao University (CN)
- Weifang Medical University (CN)
- Affiliated Hospital of Taishan Medical University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-12-30
- DOI
- https://doi.org/10.3389/fonc.2024.1492498
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.57