Intracellular α-synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular space
α-synucleinopathies progression involves the spread of α-synuclein aggregates through the extracellular space (ECS). Single-particle tracking studies showed that α-synuclein-induced neurodegeneration increases ECS molecular diffusivity. To disentangle the consequences of neuronal loss versus α-synuclein-positive intracellular assemblies formation, we performed near-infrared single-particle tracking to characterise ECS rheology in the striatum of mouse models of α-synucleinopathies. We showed that intracellular α-synuclein assemblies, without neurodegeneration, suffice to alter nanoscale diffusion in the striatal ECS.
Authors
- Benjamin Dehay (ORCID: https://orcid.org/0000-0003-1723-9045)
- Erwan Bézard (ORCID: https://orcid.org/0000-0002-0410-4638)
- Marie-Laure Arotçarena (ORCID: https://orcid.org/0000-0002-1306-3700)
- Juan Estaún‐Panzano (ORCID: https://orcid.org/0000-0003-3233-4534)
- Quentin Gresil
- Évelyne Doudnikoff (ORCID: https://orcid.org/0000-0002-3770-8585)
- Laurent Cognet (ORCID: https://orcid.org/0000-0002-3573-5387)
- Marie‐Hélène Canron (ORCID: https://orcid.org/0000-0003-1032-7632)
- Claire Mazzocco
- Somen Nandi (ORCID: https://orcid.org/0000-0001-8484-761X)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Institut des Maladies Neurodégénératives (FR)
- Laboratoire Photonique, Numérique et Nanosciences (FR)
Publication Details
- Journal
- npj Parkinson s Disease
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1038/s41531-024-00850-8
- Citations
- 3
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- European Commission
- Université de Bordeaux