Effect of gout milk and bromelain on liver and hematological parameters in male rats

Peptic ulcers occur owing to peptic acid damage to the gastrointestinal tract, resulting in the erosion of the mucosal layer, with lesions exceeding 3-5 mm in depth. Aim of the study: The main objectives of this study were to evaluate the effect of fortified goat milk on the blood, liver and hormone profile in rats by estimating them in blood plasma. To know the effect of goat milk fortified with bromelain on the stomach and intestines affected by ulcers by comparing it with the treatment of omeprazole. The research was conducted from September 2023 to January 2024. A sample of 30 sexually mature male animals was used, randomly distributed into six groups of similar weights, and each group included five rats obtained from the animal house of the College of Veterinary Medicine at Tikrit University. Division of rats occure as A1 healthy control group (untreated and provided only with water and food throughout the experiment period). A2 The infected control group (infected with a gastrointestinal ulcer after being given an oral dose of acetic acid). A3 given an oral dose of goat's milk. A4 given an oral dose of goat's milk fortified with bromelain enzyme. A5 given an oral dose of bromelain enzyme .A6 Group oral administration of omeprazole. The present study showed decrease RBC , Hb, and PCV in T2 group as compared with control(T1), while increased in T3,T4,T5, but no difference between T1 and T6. As for platelets increase in T1, while no differences between T1,T3,T4,T5,and T6. Both GPT and GOT increase in T2 as compared with T1 , while no differences in T3,T4,T5,T6 as compared with T1. Furthermore decrease T3,T4,T5,T6 as compared with T2. As for GPT decrease in T3,T4,T5,T6 as compared with T1 and T2. This study concluded the protective effect of goat milk on rats infected with peptic ulcer and synergical combination of both bromelain and gout milk were more effective than alone. This study also concluded increase PCV,Hb,RBC, and decrease GOT,and GPT in peptic ulcer.