Insulin Resistance and Propolis in Polycystic Ovary Syndrome (PCOS) Model Rats

Administering propolis delays the liver's release into the bloodstream and stimulates insulin-sensitive glucose transporters.. The purpose of this study is to assess propolis' impact on insulin resistance in mice that are PCOS model users. The control group design was restricted to post-test in laboratory experimental research. Twenty-five female Wistar rats, three months old, weighing between 100 and 130 grams, were utilised as research subjects in this study. The rats were in good health, had normal activity levels, had normal vaginal swabs, were not pregnant, and had no anatomical abnormalities. Groups K1 (negative control), K2 (positive control PCOS), P1 (PCOS + propolis 50 mg/kgBW), P2 (PCOS + propolis 100 mg/kgBW), and P3 (PCOS + propolis 200 mg/kgBW) were the five groups into which the subjects were split. kgBB). After a 21-day High Fat, High Fructose (HFHF) diet and intramuscular testosterone propionate (1.8 mg/kgBW) injection, the treatment group received propolis interventions at doses of 50 mg/kgBW (P1), 100 mg/kgBW (P2), and 200 mg/kgBB (P3) for 14 days. On the 36th day GDP, insulin, HOMA-IR, and HOMA-B values were measured. The data obtained were analysed with One-way ANOVA and the Kruskal-Wallis test and p<0.001 values were regarded as statistically significant. Propolis treatment significantly (p<0.001) lowers the levels of FBS and HOMA-IR (p<0.05), raises insulin levels and dramatically (p<0.001) raises HOMA-β values. The highest effective dose of propolis that significantly reduced insulin resistance in PCOS mice was 100 mg/kgBW. The study concluded that in PCOS model mice, propolis significantly reduced insulin resistance.