C-Reactive Protein is the Main Factor for Prediction of Fatigue in Preeclampsia Women

Preeclampsia is associated with many neuropsychiatric symptoms including fatigue. Many biomarkers are correlated with fibro fatigue (FF) scores. The present study aims to examine the changes in the advanced-glycated end-products (AGEs) and its receptor (RAGE), Vascular endothelial growth factor (VEGF) and its receptor (VEGFR1), C-reactive protein (CRP) and lipid profile and atherogenic indices in preeclampsia as predictors for preeclampsia patients with higher FF score. Preeclampsia patients were divided according to the FF score into high-FF (FF≥25) and low-FF (FF<25). The biomarkers and FF scores were measured in the patient groups and compared with healthy pregnant controls. PE women had higher levels of AGEs, RAGE, VEGF, and VEGFR1 than control women, and the rise is greater in the high-FF PE group compared with the low-FF group. PE women also have dyslipidemia and low-grade inflammation (high serum CRP), which rise with FF score. The multivariate generalized linear model (GLM) analysis showed no significant effect of the covariates (age, gestational age, gravidity, age of onset, and duration of PE) on the measured biomarkers. The study found significant differences in all parameters for high-FF PE patients (Partial η² = 0.727). CRP is the only receiver-operating characteristics (ROC) variable distinguishing high-FF PE women from low-FF PE women. The high-FF scores in PE are related to the lipid profile and atherogenic indices as well as dyslipidemia and low-grade inflammation. PE patients with high-FF can be significantly predicted by high-CRP levels.