Sex differences in the relationships between 24-h rest-activity patterns and plasma markers of Alzheimer’s disease pathology
These findings suggest that the association between disrupted circadian rest-activity patterns and AD pathophysiological processes may be more evident in cognitively unimpaired males. Our results contribute to the precision medicine approach, and they have clinical implications for improved early detection and selection of at-risk individuals to be enrolled in preventive interventions.
Authors
- Heidi I.L. Jacobs (ORCID: https://orcid.org/0000-0001-7620-3822)
- Elise Beckers (ORCID: https://orcid.org/0000-0002-5523-1741)
- Maxime Van Egroo (ORCID: https://orcid.org/0000-0002-3142-2623)
- Nicholas J. Ashton
- Henrik Zetterberg
- Kaj Blennow
Institutions
- University of Science and Technology of China (CN)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- University of Liège (BE)
- King's College London (GB)
- Stavanger University Hospital (NO)
- Sahlgrenska University Hospital (SE)
- Centre for Mental Health (GB)
- Maastricht University (NL)
- Sorbonne Université (FR)
- Massachusetts General Hospital (US)
- Institut de Myologie (FR)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- National Hospital for Neurology and Neurosurgery (GB)
- Institut du Cerveau (FR)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1186/s13195-024-01653-y
- Citations
- 4
- Primary Topic
- Sleep and related disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.03
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- BrightFocus Foundation
- Familjen Erling-Perssons Stiftelse
- Cure Alzheimer's Fund
- Stiftelsen för Gamla Tjänarinnor
- European Commission
- Universiteit Maastricht
- Hjärnfonden
- Vetenskapsrådet
- Alzheimer Nederland
- Olav Thon Stiftelsen
- National Institutes of Health
- H2020 Marie Skłodowska-Curie Actions