OGT-mediated O-GlcNAcylation regulates macrophage polarization in heart failure via targeting IRF1
Silencing of OGT promotes macrophage polarization from pro-inflammatory to anti-inflammatory phenotype to alleviate HF through O-GlcNAcylation of IRF1. The findings suggest that O-GlcNAcylation has the potential to treat HF.
Authors
- Guoqiang Jing
- Yuhong Ma (ORCID: https://orcid.org/0009-0008-3883-9211)
Institutions
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- BMC Cardiovascular Disorders
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1186/s12872-024-04429-2
- Citations
- 3
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.72