Integrated hepatic transcriptomics and metabolomics identify Pck1 as a key factor in the broad dysregulation induced by vehicle pollutants
Short-term exposure to DE induced widespread alterations in metabolic pathways in the liver of ApoE KO mice, especially involving carbohydrate and lipid metabolism, together with mitochondrial dysfunction. Pck1 was identified as a key driver gene regulating increased glucose production by activation of the gluconeogenesis pathway.
Authors
- Fen Yin
- Will Driscoll
- May Bhetraratana
- Timothy V. Larson (ORCID: https://orcid.org/0000-0003-2208-982X)
- Rajat Gupta (ORCID: https://orcid.org/0000-0003-2887-1935)
- Jesús A. Araujo (ORCID: https://orcid.org/0000-0001-8279-8922)
- Timothy R. Gould (ORCID: https://orcid.org/0000-0002-0661-9133)
- Jerry Ricks
- Allen Louie (ORCID: https://orcid.org/0000-0003-0526-1026)
- Joel D. Kaufman (ORCID: https://orcid.org/0000-0003-4174-9037)
- Gajalakshmi Ramanathan
- Xia Yang (ORCID: https://orcid.org/0000-0002-3971-038X)
- Yuqi Zhao (ORCID: https://orcid.org/0000-0003-0730-5854)
- James A. Stewart (ORCID: https://orcid.org/0000-0001-6024-6297)
- Michael E. Rosenfeld
- Siri Langmo
Institutions
- University of California, Los Angeles (US)
- University of Washington (US)
- UCLA Health (US)
Publication Details
- Journal
- Particle and Fibre Toxicology
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1186/s12989-024-00605-6
- Citations
- 5
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 1.57
Funders
- National Institutes of Health
- National Institute of Environmental Health Sciences