Live Akkermansia muciniphila boosts dendritic cell retinoic acid synthesis to modulate IL-22 activity and mitigate colitis in mice
In summary, our findings indicate that certain strains of Akk may mitigate colitis through the promotion of RA synthesis and IL-22 secretion, underscoring the potential efficacy of Akk as a therapeutic intervention for the management of UC. Video Abstract.
Authors
- Jiahui Xu (ORCID: https://orcid.org/0000-0003-2780-2217)
- Binhai Shen
- Xiuyun Ai
- Chongyang Huang (ORCID: https://orcid.org/0000-0002-9781-0258)
- Qian Zhou (ORCID: https://orcid.org/0000-0001-9304-6216)
- Xinlong Lin
- Yandong Guo
- Fachao Zhi
- Wendi Zhang (ORCID: https://orcid.org/0000-0002-6127-1408)
- Xinmei Zhao (ORCID: https://orcid.org/0000-0003-3940-788X)
- Yangyang Liu (ORCID: https://orcid.org/0000-0002-2769-7667)
- Hongbin Liu (ORCID: https://orcid.org/0000-0003-3277-1267)
- Shengbo Chen (ORCID: https://orcid.org/0000-0002-5399-709X)
- Ye Wang (ORCID: https://orcid.org/0000-0003-0764-2279)
- Ruo Huang
- Jun Wang (ORCID: https://orcid.org/0000-0002-7437-8503)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Nanfang Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1186/s40168-024-01995-7
- Citations
- 39
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 9.38
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Science and Technology Planning Project of Guangdong Province