Dapagliflozin exerts anti-apoptotic effects by mitigating macrophage polarization <i>via</i> modulation of the phosphoinositide 3-kinase/protein kinase B signaling pathway
Dapagliflozin attenuates the polarization of macrophages toward the M1 phenotype, thereby mitigating inflammation and promoting macrophage apoptosis. These effects are likely mediated through the inhibition of the PI3K/AKT signaling pathway.
Authors
- Si Xiong (ORCID: https://orcid.org/0009-0000-8979-991X)
- Cui Yong-tao
- Linjuan Huang (ORCID: https://orcid.org/0000-0003-3174-4945)
- Hanshuang Liu (ORCID: https://orcid.org/0000-0003-0960-4225)
- Xiaolei Hu (ORCID: https://orcid.org/0000-0002-9988-471X)
- Xiaoxiao Zhang (ORCID: https://orcid.org/0000-0003-3762-2287)
- Min Li (ORCID: https://orcid.org/0000-0001-6244-9055)
- Chen Shao
Institutions
- The Second Affiliated Hospital of Bengbu Medical College (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- World Journal of Diabetes
- Published
- 2024-12-30
- DOI
- https://doi.org/10.4239/wjd.v16.i2.97287
- Citations
- 6
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.44