Tacrolimus induces insulin receptor substrate 1 hyperphosphorylation and inhibits mTORc1/S6K1 cascade in HL7702 cells
Tacrolimus has no direct effect on hepatic glucose metabolism, but inhibits IRS1-mediated insulin signaling. This may be one of the underlying mechanisms by which tacrolimus induces insulin resistance.
Authors
- Yi Wang (ORCID: https://orcid.org/0000-0001-7152-0757)
- Haoyan Li (ORCID: https://orcid.org/0000-0002-6786-0705)
- Chun Xu
- Min Ran
- Bo-Yu Zhu
- Hai-Ying Xiao
- Feng Gao (ORCID: https://orcid.org/0000-0002-3791-8937)
Institutions
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- World Journal of Diabetes
- Published
- 2024-12-30
- DOI
- https://doi.org/10.4239/wjd.v16.i2.97910
- Citations
- 1
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.57