STUDY OF THE ANTIOXIDANT SYSTEM AND LIPOPEROXIDATION PROCESS IN JUDOKAS ON THE BACKGROUND OF BASIC AND COMBINED THERAPY

A study was conducted on the components of the antioxidant system: the content of superoxide dismutase (EC 1.15.1.1), catalase (EC 1.11.1.6) and α-tocopherol was studied in judokas of different ages and qualifications with rheumatoid arthritis. The studies were performed at baseline, and after the administration of antioxidant, combined therapy. During antioxidant therapy using ibuprofen (each tablet of which contains 100 mg of ascorbic acid), an increase in the activity of the studied enzymes and the concentration of α-tocopherol was noted. A positive effect of ibuprofen has been established, which is manifested, against the background of its use, by a more pronounced antioxidant effect, compared to standard, basic therapy. which helps to reduce the products of lipid peroxidation, as a result we avoid the total or partial destruction of cell membranes. We can think that due to the specificity of the training and competition processes of judokas, the optimal intensification of peroxidic oxidation of lipids occurs, and the corresponding components of the antioxidant systems are not able to completely inhibit it. Although the antioxidant therapy performed by us delays the peroxidation processes, it cannot completely inhibit the action of their toxic metabolites. In our case, this is probably due to either the low concentration of the antioxidant used or the short course of treatment with the antioxidant during the antioxidant therapy. We express an opinion: the activity of components of the antioxidant system in judokas can be increased not only by medical intervention, but also by taking physical rehabilitation and high-calorie, protein food products containing substances with antioxidant properties.