Pathophysiology, Challenges, and Public Health Implications of Malaria Coma in Low- and Middle-Income Countries

Still a life-threatening infectious disease brought on by Plasmonella parasites, malaria disproportionately affects lowand middle-income countries (LMICs), especially in sub-Saharan Africa, Southeast Asia, and some areas of Latin America.Among its serious consequences, malaria-induced coma and cerebral malaria account for most morbidity and death.Particularly in LMICs, where healthcare infrastructure is sometimes insufficient to properly handle such patients, these diseases can have terrible results including irreparable neurological damage, long-term cognitive disabilities, and death.Emphasizing deficiencies in healthcare delivery systems in resource-limited environments, this review investigates the etiology of malaria coma, its clinical characteristics, diagnostic difficulties, and present treatment approaches.It also emphasizes how urgently research to handle these important issues, access to antimalarial treatments, and development of healthcare systems must be invested in.This review intends to support the development of focused treatments to lower its burden and enhance outcomes in LMICs by offering a thorough knowledge of malaria coma.