Unraveling The Neurotherapeutic Potential of Mahakalyanaka Ghrita In Non-Motor Dimensions Of Parkinson’s Disease

Parkinson's disease (PD) is commonly associated with motor symptoms, but Non-motor features such as cognitive decline, mood disorders, sleep disturbances, and autonomic dysfunction significantly affect patients' quality of life. These non-motor symptoms often remain underrecognized and inadequately treated. Mahakalyanaka Ghrita, an Ayurvedic formulation combining ghee with medicinal herbs, is traditionally used to address neurological disorders. This conceptual review explores the potential mode of action of Mahakalyanaka Ghrita in managing the Non-motor features of Parkinson’s disease. The ingredients in this formulation possess Neuroprotective, Anti-Anti Parkinson’s, Inflammatory, Antioxidant, and Adaptogenic properties, which may help alleviate Cognitive dysfunction, Mood disorders, Sleep disturbances, Sexual dysfunctions and Autonomic dysfunction commonly seen in PD. From an Ayurvedic perspective, Mahakalyanaka Ghrita is believed to balance tridoshas, contributing to overall Neurological and Emotional well-being. The review underscores the importance of integrating Mahakalyanaka Ghrita as an adjunct to conventional therapies, with a call for further clinical studies to validate its efficacy in managing Non-motor features of Parkinson’s disease.