FUNCTIONAL DYNAMISM OF MORPHOLOGICAL CRITERIA IN THE ASSESSMENT OF DEPLETED URANIUM BIOEFFECTS IN THE STUDY OF THE ORGANOCOMPLEX OF PAROTID GLANDS AND LYMPH NODES

Currently, it is obvious that it is necessary to assess the morphofunctional state of the parotid salivary glands and lymphatic deep parotid nodes as target organs during oral intake of an aqueous solution of depleted uranium oxides. This combination has not been previously studied. The purpose of the study. To identify and evaluate, according to certain criteria, the reaction of the parotid glands and deep lymph nodes after a single incorporation of an aqueous solution of depleted uranium oxides one, three and six months after the start of the experiment. Materials and methods. The experiment involved 180 mongrel sexually mature male rats divided into three experimental groups and three control groups equivalent in age dynamics. Using histochemical and immunohistochemical methods, the organocomplex of the parotid salivary glands and deep lymph nodes was studied in the long term after a single intake of an aqueous solution of depleted uranium oxides instead of drinking water at a dose of 0.1 mg per 100 g of rat weight. Results. The prolonged bioeffect of changes in the organocomplex of the parotid glands and lymph nodes in the chronodynamics of long-term periods after incorp Conclusion. The obtained results of the study reflect uranium-induced destructive changes in the components of the organocomplex, depending on the remoteness of the study period, with the manifestation of atypical regeneration of the striated excretory ducts of the parotid glands and the dynamism of mast cells of deep lymph nodes, integratively modifying the bioeffects of depleted uranium.oration of an aqueous solution of depleted uranium oxides is shown.