DEVELOPMENT OF METHODS FOR QUALITY CONTROL OF INGREDIENTS OF COMBINED MEDICINAL PRODUCT ANTIGRIPPIN POWDER

Imported medicines to eliminate symptoms of acute respiratory viral infections prevail in the pharmaceutical market of Russia, but their share is decreasing. At the same time, drug prices are increasing. In such a situation it is necessary to optimize expenditures that would not reduce the availability and effectiveness of therapy. The solution to this problem may be the organization of small-scale production of medicines in the country. There is a demand for small-scale production in Russia, but it is still characterized as insignificant. In recent years in Russia such production has been organized at medical universities and the St. Petersburg Research Institute of Influenza. The task of such enterprises is to produce pilot batches of drugs for laboratory and clinical trials, as well as for sale through the retail network. For this purpose, the compositions of combined drug prescriptions are being unified, the production technology is being improved, experimental substantiation and extension of shelf life are being carried out, and the possibility of small-scale production is being investigated. The relevance of this study is due to the fact, that the methods of qualitative and quantitative analysis of the chemical composition of the combined medicinal product are considered. The possibility of practical application of the developed methods of analysis to assess the quality of antigrippin is shown. Scientific novelty consists in the fact that the present work is the first attempt to comprehensively evaluate the methods of analysis of antigrippin. Practical value: the work identified and analyzed the most appropriate methods of quality control antigrippin, as well as fully and in detail described the methods of analysis. The results of approbation of methods are statistically processed.