WATER-SOLUBLE SUBSTANCE BASED ON CHLORIN E6 WITH EUROPIUM CITRATE AS A POTENTIAL NEW GENERATION PHOTOSENSITIZER

The present study is directed towards synthesis a water-soluble substance for photodynamic therapy. It is an aqueous solution containing Chlorin e6 as a photosensitizer and europium citrate as a scintillator. The ionic composition of the solution was determined using ESI mass spectrometry. The conclusion was made about the nonradiative energy transfer from europium to Chlorin e6 with subsequent luminescence of the latter based on the analysis of the luminescence spectrum of the solution containing the conjugate [Eu:H2Cit:Chlorin e6=1:1:1]2-We studied dark toxicity «in vitro». It was shown that in the range of introduced PS concentrations from 3.13 to 100 μg/ml, the percentage of viable cells varied from 91.64±4.58% to 24.14±1.21%, which confirms the prospect of further study of the new substance