Rare variants in the melanocortin 4 receptor gene (MC4R) are associated with abdominal fat and insulin resistance in youth with obesity
Pathogenic variants in MC4R are associated with increased VAT, HFF%, and insulin resistance, independent from the degree of obesity in youth.
Authors
- Mark D. Ericson (ORCID: https://orcid.org/0000-0002-8715-6010)
- Sonia Caprio (ORCID: https://orcid.org/0000-0002-7523-5053)
- Domenico Tricò (ORCID: https://orcid.org/0000-0002-7633-1346)
- Jacopo Bonet (ORCID: https://orcid.org/0000-0003-4097-7943)
- Katie T. Freeman (ORCID: https://orcid.org/0000-0002-4394-0014)
- Nicola Santoro (ORCID: https://orcid.org/0000-0001-6437-4173)
- Bridget Pierpont
- Prabhath Mannam
- William M. Philbrick (ORCID: https://orcid.org/0000-0001-9219-8322)
- Brittany Galuppo (ORCID: https://orcid.org/0000-0003-4389-5118)
- Carrie Haskell‐Luevano (ORCID: https://orcid.org/0000-0002-6783-5972)
- A. Bale
Institutions
- University of Pisa (IT)
- University of Molise (IT)
- University of Minnesota (US)
- University of Padua (IT)
- Touro College (US)
- Yale University (US)
Publication Details
- Journal
- International Journal of Obesity
- Published
- 2024-12-29
- DOI
- https://doi.org/10.1038/s41366-024-01706-0
- Citations
- 1
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.27
Funders
- Yale University
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Child Health and Human Development
- National Institute on Minority Health and Health Disparities