Determinants and Outcomes of COVID-19 during the Third Wave: A Cross sectional Study

Aim: The threat of COVID-19 has since been continuing as a recurring wave with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus changing it’s variant form frequently. This study was conducted with the aim to study the clinical profile, laboratory parameters, complications, and other outcomes of patients who were hospitalized with COVID-19 infection during the third wave in a tertiary care hospital in Manipur, India. Materials and methods: This is a single-centre retrospective study, and the necessary data were collected from the medical record department of RIMS (Regional Institute of Medical Sciences) Hospital, Imphal. In this study, the case records of COVID-19 positive patients who were hospitalized in the RIMS Hospital from 1st January 2022 to 31st March 2022 has been collected. Corresponding data on demographic profile, clinical symptoms, laboratory findings, complications, and clinical outcome has been collected and compared between patients deemed as non-severe and severe cases. Results and Conclusions: The analysis included 275 confirmed COVID-19 patients, and median age was 37 years and IQR (Inter quartile range) was (27-62) years; 41.5% (n = 114) were male, and 14% (n=16) deaths. Vaccination was significantly associated with the severity of disease among the older population. Aging, duration of hospitalization and d-dimer were independent factors increasing the risk of death due to COVID-19 (p < 0.001).