Autophagy modulates glioblastoma cell sensitivity to Selinexor-mediated XPO1 inhibition
These results suggest that activation of autophagy confers a protective mechanism against Selinexor in GBM cells, and that the combination of Selinexor with autophagy inhibitors may serve as a viable means to enhance Selinexor-induced cell death.
Authors
- Hongshu Zhou
- Chuntao Li (ORCID: https://orcid.org/0000-0002-1837-0224)
- Lisa Sprinzen (ORCID: https://orcid.org/0000-0002-4885-4940)
- Xisong Liang (ORCID: https://orcid.org/0000-0001-6056-1609)
- Yukinori Terada (ORCID: https://orcid.org/0000-0002-1357-6178)
- F. Liu
- Karrie Mei Yee Kiang (ORCID: https://orcid.org/0000-0002-4354-9648)
- Yongjian Tang (ORCID: https://orcid.org/0000-0001-7564-3009)
- Liyang Zhang (ORCID: https://orcid.org/0000-0002-4054-1667)
- Bo Chen (ORCID: https://orcid.org/0000-0003-0812-5775)
- Mengli Zhang (ORCID: https://orcid.org/0000-0003-4147-394X)
- Yu Zeng (ORCID: https://orcid.org/0000-0003-4432-6443)
- Russell O. Pieper
Institutions
- Central South University (CN)
- Chinese University of Hong Kong (HK)
- University of California, San Francisco (US)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Jiangxi Provincial People's Hospital (CN)
- Jiangxi Chest Hospital (CN)
- Neurological Surgery (US)
- Xiangya Hospital Central South University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1093/neuonc/noae280
- Citations
- 6
- Primary Topic
- Nuclear Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province
- Natural Science Foundation of Hunan Province
- Xiangya Hospital, Central South University