The antiarthritic effect of CBR‐470‐1 in hypoxic environment is to increase the level of NOD‐like receptor family pyrin domain containing 3 ubiquitination by decreasing phosphoglycerate kinase 1 activity
Hypoxia plays a pro-inflammatory role by increasing PGK1 activity and thereby decreasing the ubiquitination level of NLRP3. Hypoxia plays a pro-inflammatory role by increasing PGK1 activity, reducing the binding of the deubiquitinating enzyme USP14 to NLRP3, and reducing the ubiquitination level of NLRP3. CBR-470-1 reverses the role of hypoxia in the progression of osteoarthritis.
Authors
- Zhencheng Xiong (ORCID: https://orcid.org/0000-0002-7834-5194)
- Shouye Hu (ORCID: https://orcid.org/0000-0003-3411-8771)
- Wenzheng Liu (ORCID: https://orcid.org/0000-0003-0094-301X)
- Guanglin Wang (ORCID: https://orcid.org/0000-0002-6269-5704)
- Ao Duan (ORCID: https://orcid.org/0000-0002-1019-3753)
- Xiaolong Shao (ORCID: https://orcid.org/0000-0002-6466-2586)
- Chaoyi Zhang (ORCID: https://orcid.org/0000-0001-8492-9711)
- Zemeng Ma (ORCID: https://orcid.org/0000-0002-0869-0793)
- Wei Lin (ORCID: https://orcid.org/0000-0003-1718-3539)
Institutions
- China Pharmaceutical University (CN)
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Xi'an Honghui Hospital (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1002/ctm2.70118
- Citations
- 1
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Natural Science Foundation of Sichuan Province