Trends in Research on The Effects of Nutritional Supplements Against Nephrotoxicity; A Bibliometric Study

Aim; Publications investigating the potential of various nutritional supplements such as antioxidants, probiotics, and phytochemicals to improve drug-induced nephrotoxicity has increased both qualitatively and quantitatively over the years. This bibliometric analysis evaluated highly cited 100 articles on the protective effects of nutritional supplements against nephrotoxicity published between 2010 and 2023. Method; Articles published in these 13 years were evaluated through structured search in Scopus and Web of Science databases. Statistics and visualization techniques were done with VOSviewer and RStudio software. Results; The increase rate of articles published on this subject was found to be %450. The average h-index of selected studies was calculated as 60. A total of 534 authors and a citation rate of 86.95 were determined. The total citation mean was determined as 9 per year. The top 3 supplements were curcumin (n=7) melatonin and probiotics (n=5) in the trends. Cisplatin and gentamicin are used as toxic agents in 34% of the top 100 articles we researched, and they continue to be a trend. Conclusion; Trending and effective supplements in this field are curcumin, melatonin, berberine, quercetin and probiotics. Based on our investigations, we think that, the synergistic between the effective bioactive ingredients with probiotics and/or other functional foods suggest future novel approaches based on interactions involving microbiota, oxidative and inflammatory stress.