Insulin resistance or hyperinsulinemia, a risk factor for Gestational Diabetes Mellitus

We have overlooked an important factor in Gestational diabetes and diabetes pathogenesis. Insulin resistance (IR) and the associated hyperinsulinemia represent the earliest risk factors and risk factors responsible for a pandemic of diabetes and Cardiovascular diseases [1]. As a result, they are not screened early and are not treated for preventive purposes [2,3]. Its prevalence has reached up to 51% of the population in developed and developing countries. IR/Hyperins can precede the onset of type 2 diabetes by up to 15 years. Hyperins are responsible for endothelial dysfunction, hypercholesterolemia, concentric remodeling of the left ventricle, and systemic arterial hypertension (due to the prevalence of endothelin-1 over nitric oxide secretion, the activation of the sympathetic nervous system and the anti-natriuretic effect). In addition, excessively high levels of circulating insulin act as a growth factor, binding not only to insulin receptors but also to insulin-like growth factor-1 receptors,with negative consequences for the development of tumours