Lymphoproliferative tumors in rheumatic diseases

The development of lymphoid tumors in patients with rheumatic diseases can significantly worsen the quality of life and negatively affect the prognosis. The article presents modern data on the relationship between lymphoid tumors and rheumatic diseases. Practical differential diagnosis guidelines of T cell large granular lymphocytic leukemia in patients with rheumatoid arthritis and Felty’s syndrome are given. The results of the study of pathogenesis and bio‑ logical predictors of diffuse large B cell lymphoma in patients with rheumatic diseases are presented. This study of the lymphoproliferative tumor pathogenesis in patients with rheumatic diseases sheds light on the mechanisms underlying the development of sporadic lymphoproliferative tumors and autoimmune diseases, as well as on the pro‑ gress in the treatment of these diseases.