Wound Healing in Diabetic foot Ulceration by Using Fat-Derived Stromal Vascular Matrix (SVM) Therapy - A Case Series

Some chronic wounds, such as diabetic foot ulcerations, remain constantly resistant to treatment, leading to serious outcomes such as severe infections, limb loss, and even loss of life despite adequate consideration of the underlying disease and causal therapy approaches.Another promising approach involves Mesenchymal Stem Cells (MSCs) isolated from different potential sources.We report on a case series of five cases of refractory diabetic foot lesions that were successfully treated by using a fat-derived Stromal Vascular Matrix (SVM) therapy.SVM is a novel technology that provides sufficient cell counts and viability for effective wound care management.In all cases, the SVM application was resulting in satisfactory wound size reduction up to healing during a follow-up period of about six weeks.To our knowledge, this case series is the first to document outcomes of SVM in wound care.As there currently is insufficient data on the use of SVM in any phase of chronic wound care, further research is needed to determine the optimal timing for its application.Nevertheless, we believe that further observation of this new technology in the treatment of nonhealing chronic wounds is absolutely worthwhile.