A hexanuclear cerium(IV) complex with the non–steroidal anti–inflammatory drug mefenamic acid
A hexanuclear cerium(IV) complex with a non–steroidal anti–inflammatory drug mefenamic acid (Hmef) as a ligand has been synthesized and characterized by diverse techniques. The molecular structure of the complex was determined by single–crystal X–ray crystallography revealing the formula [Ce<sub>6</sub>(O)<sub>4</sub>(OH)<sub>4</sub>(mef)<sub>12</sub>(DMF)<sub>2</sub>]. The antioxidant activity of the complex was evaluated for its ability to scavenge free radicals. The interaction of the complex with calf–thymus DNA was studied by diverse techniques showing its potency to intercalate to DNA. The interaction of the complex for human and bovine serum albumins was studied by fluorescence emission spectroscopy and revealed its tight and reversible binding to the albumins.
Authors
- Antonios G. Hatzidimitriou (ORCID: https://orcid.org/0000-0001-6237-126X)
- George Psomas (ORCID: https://orcid.org/0000-0002-5879-7265)
- Spyros Perontsis
- Vladimiros Chrysoulidis
Institutions
- Aristotle University of Thessaloniki (GR)
Publication Details
- Journal
- Journal of Coordination Chemistry
- Published
- 2024-12-28
- DOI
- https://doi.org/10.1080/00958972.2024.2445210
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00