HIF-1α mediates hypertension and vascular remodeling in sleep apnea via hippo–YAP pathway activation
Our findings demonstrate the significance of the HIF-1α/Hippo-YAP pathway in CIH-induced hypertension and vascular remodeling. HIF-1α contributes to these pathophysiological processes by promoting oxidative stress, inflammation, and aberrant VSMC behavior. Targeting this pathway could offer new therapeutic strategies for CIH-related cardiovascular complications in SAS patients.
Authors
- Guojin Zhou
- Hong Pan (ORCID: https://orcid.org/0000-0002-5063-7347)
- Mang Xiao (ORCID: https://orcid.org/0000-0002-7131-6251)
- Yuan Zhao (ORCID: https://orcid.org/0000-0002-7573-4936)
- Zheng Dong (ORCID: https://orcid.org/0000-0003-3538-8095)
- Mina L. Xu (ORCID: https://orcid.org/0000-0001-9513-245X)
- Shoude Zhang (ORCID: https://orcid.org/0000-0002-4254-9195)
- Mao Jin (ORCID: https://orcid.org/0009-0006-0604-1382)
- Ying Lu (ORCID: https://orcid.org/0000-0002-6424-5424)
Institutions
- Xinjiang Medical University (CN)
- Sir Run Run Shaw Hospital (CN)
- Sixth Affiliated Hospital of Xinjiang Medical University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-12-28
- DOI
- https://doi.org/10.1186/s10020-024-00987-5
- Citations
- 7
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 2.28