Rising Burden and Disparities in the Prevalence of Hidradenitis Suppurativa

This study investigates the prevalence trends of hidradenitis suppurativa across sex, race, and age groups in the United States from 2014 to 2023 using data from the TriNetX Research Network. A retrospective, population-based approach was employed to analyze de-identified electronic health records encompassing over a decade of data. Results revealed a significant rise in prevalence, nearly quadrupling from 0.222% in 2014 to 0.842% in 2023, with females consistently exhibiting higher rates than males, widening from a 0.203% gap in 2014 to 0.736% in 2023. Racial disparities were striking, with African Americans experiencing the highest prevalence (2.109% in 2023) compared to Caucasians (0.691%) and Asians (0.334%). Age-specific patterns showed the greatest burden in the 15–29 age group (1.7% in 2023) and substantial increases in adolescents and middle-aged adults, while older populations (≥70 years) exhibited minimal changes. These findings highlight significant disparities across demographic subgroups, underscoring the need for targeted public health interventions, equitable healthcare policies, and further research into underlying drivers.