<i>Acanthamoeba</i> Infection in a Hematopoietic Cell Transplant Recipient: Challenges in Diagnosis, Management, and Source Identification
We report a case of Acanthamoeba infection in an HCT recipient with steroid-refractory GVHD. We highlight the multiple challenges that free-living ameba infections present to the clinician, the clinical laboratory, transplant infectious disease for review, hospital epidemiology if nosocomial transmission is considered, and public health officials, as exposure source identification can be a significant challenge. Transplant physicians should include Acanthamoeba infections in their differential diagnosis of a patient with skin, sinus, lung, and/or brain involvement.
Authors
- Camellia T. Banerjee
- Clay Deming (ORCID: https://orcid.org/0000-0002-7745-1518)
- Angela V. Michelin
- Juan Gea‐Banacloche (ORCID: https://orcid.org/0000-0003-0310-7172)
- Matthew J. Arduino (ORCID: https://orcid.org/0000-0001-7072-538X)
- Alison Han (ORCID: https://orcid.org/0000-0002-7622-7696)
- Jennifer Cuellar‐Rodríguez (ORCID: https://orcid.org/0000-0001-5298-6463)
- Sean Conlan (ORCID: https://orcid.org/0000-0001-6848-3465)
- Bickey H. Chang (ORCID: https://orcid.org/0000-0003-3522-8198)
- Seyedmojtaba Seyedmousavi (ORCID: https://orcid.org/0000-0002-6194-7447)
- Anahita Mostaghim
- Elise M. O’Connell (ORCID: https://orcid.org/0000-0001-9425-2011)
- Martha Quezado (ORCID: https://orcid.org/0009-0004-0941-8662)
- Christopher George Kanakry (ORCID: https://orcid.org/0000-0002-7736-2056)
- Julia C. Haston (ORCID: https://orcid.org/0000-0002-4974-919X)
- Mia Mattioli (ORCID: https://orcid.org/0000-0002-7318-5240)
- Julia A. Segre (ORCID: https://orcid.org/0000-0001-6860-348X)
- Sanchita Das (ORCID: https://orcid.org/0009-0008-1369-5688)
- Akbulut Dilara
Institutions
- National Institutes of Health (US)
- National Human Genome Research Institute (US)
- National Center for Emerging and Zoonotic Infectious Diseases (US)
- National Institute of Allergy and Infectious Diseases (US)
- National Cancer Institute (US)
- Office of Extramural Research (US)
- Center for Cancer Research (US)
- National Institutes of Health Clinical Center (US)
Publication Details
- Journal
- Transplant Infectious Disease
- Published
- 2024-12-28
- DOI
- https://doi.org/10.1111/tid.14425
- Citations
- 1
- Primary Topic
- Legionella and Acanthamoeba research
- Type
- article
- Field-Weighted Citation Impact
- 0.62
Funders
- National Institutes of Health
- Centers for Disease Control and Prevention
- National Human Genome Research Institute
- National Institute of Allergy and Infectious Diseases