Brain phosphoproteomic analysis identifies diabetes‐related substrates in Alzheimer's disease pathology in older adults
The risk of Alzheimer's disease (AD) dementia is increased among older adults living with diabetes. The patterns of AD-related phosphoprotein in the human brain in older adults are differential among older adults living with diabetes. Microtubule-associated protein tau phosphorylated at T529 and T534 (isoform 8 T212 and T217) showed differential associations with diabetes. Phosphosite co-abundance networks of synergistic interactions between AD and diabetes were identified.
Authors
- Shinya Tasaki (ORCID: https://orcid.org/0000-0003-3656-7394)
- Vishal Sarsani (ORCID: https://orcid.org/0000-0002-9272-3438)
- David Alan Bennett (ORCID: https://orcid.org/0000-0003-3689-554X)
- Ana W. Capuano (ORCID: https://orcid.org/0000-0002-3505-344X)
- Zoe Arvanitakis (ORCID: https://orcid.org/0000-0001-7477-8884)
- Liming Liang (ORCID: https://orcid.org/0000-0001-8261-3174)
- Vladislav Petyuk (ORCID: https://orcid.org/0000-0003-4076-151X)
- Rexford S. Ahima (ORCID: https://orcid.org/0000-0002-3479-1942)
- Rupal I. Mehta (ORCID: https://orcid.org/0000-0003-4917-6907)
- Steven Edward Arnold (ORCID: https://orcid.org/0000-0002-9487-415X)
- Jun Li (ORCID: https://orcid.org/0000-0002-2868-9511)
Institutions
- Brigham and Women's Hospital (US)
- Rush University Medical Center (US)
- Harvard University (US)
- Pacific Northwest National Laboratory (US)
- Johns Hopkins University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-28
- DOI
- https://doi.org/10.1002/alz.14460
- Citations
- 6
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.96
Funders
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke