Plasma phosphorylated tau and neuropsychiatric symptoms in dementia with Lewy bodies
Neuropsychiatric symptoms (NPSs) were more common in dementia with Lewy bodies (DLB) than in Alzheimer's disease (AD). Lower plasma phosphorylated tau-231 (p-tau231) and p-tau181 levels were associated with persistent hallucinations in DLB. Lower plasma p-tau231 and p-tau181 levels were associated with an increased risk of persistent NPSs in early DLB. Hallucinations at baseline were associated with greater cognitive dysfunction in DLB, and there was an interaction with p-tau231.
Authors
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- Maria Camila González (ORCID: https://orcid.org/0000-0003-1061-4164)
- Andrea Pilotto (ORCID: https://orcid.org/0000-0003-2029-6606)
- Afina W. Lemstra (ORCID: https://orcid.org/0000-0002-8933-3260)
- Clive Ballard (ORCID: https://orcid.org/0000-0003-0022-5632)
- Dag Aarsland (ORCID: https://orcid.org/0000-0001-6314-216X)
- Diego Tovar (ORCID: https://orcid.org/0000-0003-3490-9899)
- Lucy L. Gibson (ORCID: https://orcid.org/0000-0002-9815-3616)
- Claire Paquet (ORCID: https://orcid.org/0000-0002-2273-7316)
- Henrik Zetterberg
- Frederic Blanc
Institutions
- University of Wisconsin–Madison (US)
- University of Arizona (US)
- King's College London (GB)
- Université Paris Cité (FR)
- University of Exeter (GB)
- Stavanger University Hospital (NO)
- Hong Kong Science and Technology Parks Corporation (HK)
- Sahlgrenska University Hospital (SE)
- Centre for Mental Health (GB)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Fernand-Widal (FR)
- UK Dementia Research Institute (GB)
- Banner Sun Health Research Institute (US)
- National Hospital for Neurology and Neurosurgery (GB)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
- Université de Strasbourg (FR)
- University of Brescia (IT)
- University of Gothenburg (SE)
- University of Stavanger (NO)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-28
- DOI
- https://doi.org/10.1002/alz.14434
- Citations
- 5
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Familjen Erling-Perssons Stiftelse
- Cure Alzheimer's Fund
- EU Joint Programme – Neurodegenerative Disease Research
- Alzheimer's Society
- National Institute for Health and Care Research
- University College London
- European Commission
- Ministero della Salute
- Hjärnfonden
- Vetenskapsrådet
- UK Dementia Research Institute
- Associazione Italiana Ricerca Alzheimer
- Université de Paris
- Horizon 2020 Framework Programme
- HORIZON EUROPE Framework Programme