Early midlife ovarian removal is associated with lower posterior hippocampal function
After ovarian removal, changes in hippocampal function may affect dementia risk. Midlife ovarian removal is associated with less activation in the posterior hippocampus. Estradiol therapy may ameliorate alterations in brain function during learning.
Authors
- Morgan D. Barense (ORCID: https://orcid.org/0000-0002-4008-9201)
- Marcus Q. Bernardini (ORCID: https://orcid.org/0000-0001-7022-8308)
- Sophia Zhao (ORCID: https://orcid.org/0009-0008-6914-3583)
- Alana Brown (ORCID: https://orcid.org/0000-0002-1237-1314)
- Preben Kjølhede (ORCID: https://orcid.org/0000-0001-5702-4116)
- Suzanne T. Witt (ORCID: https://orcid.org/0000-0002-5530-0807)
- Laura L. Gravelsins (ORCID: https://orcid.org/0000-0002-9087-9199)
- Jenny Rieck (ORCID: https://orcid.org/0000-0002-3242-6407)
- Cheryl Grady (ORCID: https://orcid.org/0000-0001-9533-8802)
- Nicole Gervais (ORCID: https://orcid.org/0000-0003-2773-7830)
- Robin Kämpe (ORCID: https://orcid.org/0000-0002-1107-5644)
- Jan Ernerudh (ORCID: https://orcid.org/0000-0001-9456-2044)
- M. Natasha Rajah (ORCID: https://orcid.org/0000-0001-6177-7049)
- Annie Duchesne (ORCID: https://orcid.org/0000-0001-6049-8785)
- Elisabeth Åvall‐Lundqvist (ORCID: https://orcid.org/0000-0001-7274-1770)
- Rosanna K. Olsen (ORCID: https://orcid.org/0000-0002-2918-4152)
- Elisabet Classon (ORCID: https://orcid.org/0000-0003-1403-6357)
- Gillian Einstein (ORCID: https://orcid.org/0000-0002-0770-5471)
- Maria Engström (ORCID: https://orcid.org/0000-0002-2167-2450)
- Elvar Theodorsson (ORCID: https://orcid.org/0000-0003-0756-7723)
- Michelle Jacobson
- Zhuo Shao
Institutions
- Linköping University (SE)
- Western University (CA)
- University of Northern British Columbia (CA)
- University of Groningen (NL)
- University of Toronto (CA)
- North York General Hospital (CA)
- Women's College Hospital (CA)
- Baycrest Hospital (CA)
- Princess Margaret Cancer Centre (CA)
- Toronto Metropolitan University (CA)
- Université du Québec à Trois-Rivières (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-28
- DOI
- https://doi.org/10.1002/alz.14447
- Citations
- 4
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Alzheimer's Association
- McGill University
- Ontario Brain Institute
- Fondation Brain Canada
- Forskningsrådet i Sydöstra Sverige
- Alzheimer Society
- Canadian Cancer Society
- Canada Research Chairs
- Cancerfonden
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Medical Research Council