Longitudinal synaptic loss versus tau Braak staging in amnestic mild cognitive impairment
Tau accumulation reached a plateau in early Braak regions in amnestic mild cognitive impairment (aMCI) patients. aMCI patients show widespread longitudinal decrease in synaptic vesicle protein 2A (SV2A) over 2 years. Baseline tau was predictive for longitudinal SV2A loss. The tau-SV2A relation showed individual variability and was negative across patients. Baseline tau and longitudinal SV2A change were associated with change in cognition.
Authors
- Laura Michiels (ORCID: https://orcid.org/0000-0002-1208-5334)
- Robin Lemmens (ORCID: https://orcid.org/0000-0003-3374-1502)
- Greet Vanderlinden (ORCID: https://orcid.org/0000-0002-5673-4121)
- Michel Koole (ORCID: https://orcid.org/0000-0001-5862-640X)
- Mathieu Vandenbulcke (ORCID: https://orcid.org/0000-0001-9765-1499)
- Koen Van Laere (ORCID: https://orcid.org/0000-0001-5200-7245)
Institutions
- Universitair Ziekenhuis Leuven (BE)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-28
- DOI
- https://doi.org/10.1002/alz.14412
- Citations
- 12
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.92
Funders
- Fonds Wetenschappelijk Onderzoek
- KU Leuven