Ferroptosis: Basic Mechanisms, Key-Factors and The Role of The Diseases

Research on the explosive growth of Ferroptosis in the past decade. Ferroptosis is the way of cell death that causes lipid peroxidation, and there are a variety of inducers for Ferroptosis that can lead to a decrease in cell antioxidant capacity and the accumulation of lipid reactive oxygen species(ROS) of through multiple regulatory pathways, which leads to cell membrane damage and eventually leads to cell oxidative death. It will lead to a series of related diseases and plays a crucial role as a tumour suppressor mechanism. In this review, the relevant regulatory mechanisms of ferroptosis (especially the conventional ferroptosis pathway) are specifically summarised and the relevant diseases associated with ferroptosis are described. Fortunately, by initiating and reducing ferroptosis, there is significant potential to treat drug-resistant malignancies, ischemic organ damage, and other degenerative disorders linked to severe lipid peroxidation. Importantly, there are still a lot of obstacles to ferroptosis, and this review offers pertinent research suggestions to overcome these problems. Lastly, this article discusses the specific applicability of ferroptosis to disease; future ferroptosis research should center on these challenges.