Exosomes derived from umbilical cord mesenchymal stem cells promote healing of complex perianal fistulas in rats
The hUCMSCs-Exo significantly promoted the healing of wound in perianal fistulas of rats and demonstrated higher safety. The underlying mechanism facilitating the healing process was likely associated with the activation of the HIF-1α/TGF-β/Smad signaling pathway.
Authors
- Yafei Lu (ORCID: https://orcid.org/0009-0000-6931-2852)
- Shaohua Huangfu
- Lianming Liao (ORCID: https://orcid.org/0000-0003-0248-0821)
- Chungen Zhou
- Ao Chen (ORCID: https://orcid.org/0000-0002-9699-8340)
- Min Li (ORCID: https://orcid.org/0000-0002-7113-2700)
- Yajie Zhang (ORCID: https://orcid.org/0000-0001-5570-5436)
- Yuting Chen (ORCID: https://orcid.org/0000-0003-4661-2048)
- Dawei Wang (ORCID: https://orcid.org/0000-0002-6151-5839)
- Jia You
- Bin Jiang (ORCID: https://orcid.org/0000-0002-4622-9703)
- Chuanxue Ma
- Yan Ding
Institutions
- Fujian Medical University (CN)
- Nanjing University of Chinese Medicine (CN)
- Anhui University of Traditional Chinese Medicine (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-12-29
- DOI
- https://doi.org/10.1186/s13287-024-04028-0
- Citations
- 13
- Primary Topic
- Anorectal Disease Treatments and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 7.45
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province