Room-temperature synthesis of Fe3O4@MOF-5 magnetic hybrid as an efficient catalyst for the one-pot green synthesis of tetrahydropyridines

In recent two decades, considerable efforts have been devoted to the room-temperature green syntheses of metal-organic frameworks (MOFs) to reduce energy consumption and increase safety. It could improve some properties (e.g., catalysis, gas adsorption) and facilitate the utilities of sensitive compounds. Herein, the magnetic hybrid catalyst (Fe₃O₄@MOF-5) was synthesized through a mixing procedure at room temperature and confirmed by various techniques. The SEM images exhibit cubic crystals that were uniformly coated by the Fe₃O₄ cores. Then, the catalytic ability of Fe₃O₄@MOF-5 was studied in the green synthesis of tetrahydropyridines via a domino multi-component reaction, which led to the desired products with high yield. Magnetic solid properties make it easily separated from the reaction medium, so the proposed catalyst can be reused five times while maintaining the catalytic activity over 80%.