Amoxicillin Blood Concentration in High-Dose Intravenous Discontinuous Amoxicillin: Look Beyond Numbers. Max-Amox Study
Variability in ATPC was high and ATPC cannot be considered as the only monitoring tool to adjust amoxicillin dosage. High ATPC, low urinary pH, and presence of AC can alert physicians to a potential iatrogenic effect and lead to the decision to hydrate the patient, alkalinize urine and decrease the dosage of amoxicillin.
Authors
- Delphine Martineau (ORCID: https://orcid.org/0000-0003-0327-2936)
- F. Anglade
- Damien Richard (ORCID: https://orcid.org/0000-0001-9179-7315)
- Claire Dupuis
- Guillaume Clerfond (ORCID: https://orcid.org/0000-0001-6625-5178)
- Melissa Clément
- M. Vidal (ORCID: https://orcid.org/0000-0002-3977-9846)
- M. Ruivard
- Claude Dubray (ORCID: https://orcid.org/0000-0002-8240-0352)
- Bruno Pereira (ORCID: https://orcid.org/0000-0001-6102-4530)
- Anne Tournadre (ORCID: https://orcid.org/0000-0002-5025-0214)
- Étienne Geoffroy
- Xavier Moisset (ORCID: https://orcid.org/0000-0002-8799-0750)
- L. Gibold
- Marc André
Institutions
- Physiopathologie et pharmacologie de la douleur et de la migraine (FR)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
Publication Details
- Journal
- Clinical Therapeutics
- Published
- 2024-12-28
- DOI
- https://doi.org/10.1016/j.clinthera.2024.12.003
- Citations
- 3
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 1.34