Towards a histological diagnosis of childhood small vessel CNS vasculitis
Distinct histological features were identified in sv-cPACNS biopsies, including moderate to severe angiocentric inflammatory infiltrates in the cortex or white matter, consisting of CD3, CD4, CD8, and CD20 cells, alongside reactive endothelium with specificity of 95%. In the first study of its kind proposing histological criteria for evaluating brain biopsies, we aim to precisely characterize the type and severity of the inflammatory response in patients with sv-cPACNS; this can enable consolidation of this population to assess outcomes and treatment methodologies comprehensively.
Authors
- Harry V. Vinters
- Jean Michaud (ORCID: https://orcid.org/0000-0003-3883-4484)
- Anastasia Dropol
- Saira Sheikh
- Peter W. Schütz (ORCID: https://orcid.org/0000-0001-7962-1560)
- Susanne M. Benseler (ORCID: https://orcid.org/0000-0001-5756-3638)
- Benjamin Ellezam (ORCID: https://orcid.org/0000-0002-8716-7924)
- Pascal N. Tyrrell (ORCID: https://orcid.org/0000-0003-2277-3824)
- Harvey B. Sarnat (ORCID: https://orcid.org/0000-0002-6953-2959)
- Marinka Twilt (ORCID: https://orcid.org/0000-0003-1954-2822)
- Christopher Dunham (ORCID: https://orcid.org/0000-0002-6244-0584)
- Julia Keith (ORCID: https://orcid.org/0000-0003-1519-6731)
- Cynthia Hawkins (ORCID: https://orcid.org/0000-0003-2618-4402)
- David G. Muñoz (ORCID: https://orcid.org/0000-0003-0957-6244)
- Maryam Nabavi Nouri (ORCID: https://orcid.org/0000-0001-6317-4890)
Institutions
- Western University (CA)
- St. Michael's Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- University of British Columbia (CA)
- University of Ottawa (CA)
- University of Calgary (CA)
- University of Toronto (CA)
- Children's Hospital of Eastern Ontario (CA)
- Ronald Reagan UCLA Medical Center (US)
- Hospital for Sick Children (CA)
- Alberta Children's Hospital (CA)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Health Sciences Centre (CA)
- Children's & Women's Health Centre of British Columbia (CA)
- SickKids Foundation (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Pediatric Rheumatology
- Published
- 2024-12-28
- DOI
- https://doi.org/10.1186/s12969-024-01053-4
- Citations
- 2
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.84