The Novel SSTR3 Full Agonist ITF2984 Shows Antitumor Properties against Pancreatic Neuroendocrine Tumors
We found that ITF2984 is as effective as pasireotide at inhibiting both proliferation/viability and hormone secretion, as well as at inducing apoptosis of Pan-NET cells grown as both 2D monolayers and 3D spheroids. High-dose ITF2984 elicits structural alterations in Pan-NET 3D spheroids compatible with cell death more effectively than pasireotide. Altogether, ITF2984 may represent a useful alternative to pasireotide for the medical treatment of Pan-NETs and other tumors with elevated SSTR3 expression.
Authors
- Natalia S. Pellegata (ORCID: https://orcid.org/0000-0002-8000-7784)
- Frank J. Ascione (ORCID: https://orcid.org/0000-0002-8087-3148)
- Franco Fedeli
- Alessandro Marangelo
- Daniela Modena
- Christian Steinkühler (ORCID: https://orcid.org/0000-0001-8341-9699)
- Jörg Schrader
- Margarita Bistika
- Nicole Valentini
Institutions
- Heidelberg University (DE)
- University of Pavia (IT)
- University Hospital Heidelberg (DE)
- Helmholtz Zentrum München (DE)
- Italfarmaco (Italy) (IT)
Publication Details
- Journal
- Neuroendocrinology
- Published
- 2024-12-28
- DOI
- https://doi.org/10.1159/000543136
- Citations
- 2
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.77