High Frequency of CTNNB1 Variants Associated with Benign and Malignant Liver Tumors in Patients with Congenital Porto-Systemic Shunts
CPSS is strongly associated with nodules containing variants in <i>CTNNB1</i>, irrespective of the histological category. Areas in background liver containing these variants were also identified, and different variants could be identified in individual patients. The high proportion of <i>CTNNB1</i> variants may explain the higher malignant potential of benign tumors found in CPSS.
Authors
- Sandra Strautnieks
- Mark Davenport (ORCID: https://orcid.org/0000-0002-0938-2717)
- Pierre Foskett
- Athanasios Tyraskis
- Maesha Deheragoda
- Yoh Zen (ORCID: https://orcid.org/0000-0001-8370-6508)
- Nigel Heaton
- Robert F. Cook (ORCID: https://orcid.org/0000-0003-0422-8881)
- Claudio De Vito (ORCID: https://orcid.org/0000-0002-4966-1278)
- Alberto Quaglia (ORCID: https://orcid.org/0000-0002-3333-3579)
- Richard J. Thompson
Institutions
- King's College London (GB)
- The Royal Free Hospital (GB)
- University Hospital of Geneva (CH)
- King's College Hospital NHS Foundation Trust (GB)
- King's College Hospital (GB)
- University College London (GB)
Publication Details
- Journal
- Liver Cancer
- Published
- 2024-12-28
- DOI
- https://doi.org/10.1159/000543217
- Citations
- 1
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.55
Funders
- Children's Liver Disease Foundation
- King's College London
- King's Health Partners