Influence of perioperative therapy on filtration bleb formation and ophthalmotonus level after glaucoma surgery

Introduction. One limitation of glaucoma surgery is its reduced long-term effectiveness due to scarring of intraocular fluid outflow pathways. Appropriate perioperative therapy may extend the hypotensive effect by reducing scarring and improving the filtration bleb. Purpose: to evaluate the effect of perioperative use of Oku-Oku® on intraocular pressure (IOP) and filtration bleb condition in the early postoperative period following glaucoma surgery. Materials and methods. Thirty patients (30 eyes) who underwent non-penetrating glaucoma surgery (NPGS) were studied. The main group (15 eyes) received Oku-Oku® drops twice daily: the day before surgery, immediately before surgery, and for five days postoperatively. The control group (15 eyes) received no additional medication. Tonometry and assessment of conjunctival hyperemia were performed the day before surgery, and at 1 day, 2 weeks, and 1 month postoperatively. Filtration bleb characteristics were assessed using the Würzburg Clinical and Morphological Classification of Filtration Pads at the same time points, except for the preoperative assessment. Results. Glaucoma surgery significantly reduced IOP in both groups. After 1 month, the mean IOP in the main group was lower (15.1 ± 4.1 mm Hg) compared to the control group (17.9 ± 3.3 mm Hg). Conjunctival hyperemia was also lower in the main group (15.4 ± 2.7%) than in the control group (18.0 ± 3.1%). Filtration bleb parameters improved in both groups over time, with the greatest differences observed at 1 day and 2 weeks post-surgery. Conclusion. Perioperative use of Oku-Oku® reduced conjunctival hyperemia in the filtration bleb area during the first month after glaucoma surgery. This early improvement in the intraocular fluid deposition area may enhance the effectiveness of glaucoma surgery. Oku-Oku® can be used in comprehensive preparation for glaucoma surgery and other similar anterior segment procedures.