Review on Ketoprofen (Anti-Inflammatory Drug)

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) widely utilized for its analgesic, anti-inflammatory, and antipyretic properties. This review article examines ketoprofen's pharmacological profile, efficacy, and therapeutic applications, particularly in the management of acute and chronic pain, including dysmenorrhea, osteoarthritis, and rheumatoid arthritis. Ketoprofen exerts its effect by inhibiting the cyclooxygenase (COX) enzymes, COX-1 and COX- 2, reducing the synthesis of prostaglandins responsible for pain and inflammation. Various formulations of ketoprofen are available, including oral tablets, topical gels, suppositories, and injectables, each tailored to specific clinical needs and patient preferences. Recent advancements in topical and extended-release formulations have improved patient adherence and minimized gastrointestinal side effects traditionally associated with NSAIDs. However, ketoprofen remains contraindicated in patients with certain cardiovascular, renal, and gastrointestinal conditions, underscoring the need for careful patient selection and dosage adjustment. This review highlights ketoprofen's clinical efficacy, safety profile, and evolving therapeutic applications, providing insight into its role within the broader scope of pain management strategies.